Buy IGF-1 LR3 Online
Buy IGF-1 LR3 Online – is an 83 amino acid analog of human IGF-I composed in fact of the complete sequence of human IGF-1, but with the substitution of Arg for Glu at position 3, and than a 13 amino acid extension peptide at the N-terminus. This combination makes Long R3IGF-I seemingly more potent (2-3x) than IGF-I in the studies because it has a lower affinity for being made passive by IGF-binding proteins and, therefore, more potential activity in the body.
IGF-1 LR3 is also referred to as Long Arg3 IGF-1, a recombinant analogous human insulin-like growth factor protein with a molecular weight of 9,200 Daltons and composed of 83 amino acids. IGF-1 LR3 comprises the complete sequence of IGF-1, but with a 13-amino acid extension on the B-Terminus domain and the substitution of an arginine for glutamic acid at position 3. The LR3 analogue of the IGF-1 was created with the intention of significantly increasing the biological activity of the protein and IGF-LR3 is several times more potent than rhIGF-1. This sequence alteration in particular has decreased IGFBP binding affinity, which controls the biological actions of IGF-1 and prevents the protein from reaching the IGF-1 receptors.
IGF-1 LR3 is an 83-amino acid human IGF-1 analog that has been modified to include a 13-amino acid extension on its N-terminus and replacement of an arginine amino acid by glutamine in position 3. While IGF-1 LR3 comprises the complete sequence of human IGF-1, these modifications have made the LR3 version much more potent than IGF-1 in vitro and in vivo. The result of these modifications is that IGF-1 LR3 does not bind as strongly to IGFBPs, which modify the biological actions of IGF-1.
As a result, IGF-1 LR3 binds to the type 1 IGF-1 receptor with similar affinity to wild-type IGF-1, but with superior biological activity and several points. positive compared to recombinant insulin.
The substitution of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in higher productivity than that achieved with standard insulin and / or standard IGF-1 concentrations. IGF-1 LR3 is better able to stimulate the type 1 IGF receptor and thus induces a higher level of activation of intracellular signaling, promoting cell proliferation and inhibition. of apoptosis.